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Efineptakin alfa - Genexine

Drug Profile

Efineptakin alfa - Genexine

Alternative Names: GX 17; GX-I7; HyLeukin; HyLeukin-7™; IL-7-hyFc; Interleukin-7-hybrid-Fc-recombinant-protein; NT-17; Recombinant human IL-7-hyFc; rhIL-7-hyFc; TJ 107

Latest Information Update: 21 Feb 2020

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At a glance

  • Originator Genexine
  • Developer Genexine; I-MAB Biopharma; Merck & Co; NeoImmuneTech
  • Class Antineoplastics; Antivirals; Immunoglobulin Fc fragments; Interleukins; Recombinant fusion proteins; Recombinant proteins
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Immunostimulants; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Leucopenia; Idiopathic CD4-positive T-lymphocytopenia
  • New Molecular Entity No

Highest Development Phases

  • Phase I/II Breast cancer; Glioblastoma; Skin cancer; Solid tumours
  • Phase I Cervical intraepithelial neoplasia; Human papillomavirus infections; Leucopenia
  • Preclinical Lymphoma

Most Recent Events

  • 27 Jan 2020 The US FDA approves IND application for a phase Ib/IIa trial for efineptakin alfa in Solid tumours (Combination therapy, Late-stage disease, Second-line therapy or greater)
  • 27 Jan 2020 NeoImmuneTech and Merck Sharp & Dohme plans a phase Ib/IIa trial for Solid tumours (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA
  • 26 Dec 2019 Phase-I/II clinical trials in Skin cancer (Combination therapy, Late-stage disease) in USA (IM) (NCT03901573)
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