Research programme: HBV DNA destabiliser - Arbutus Biopharma

Drug Profile

Research programme: HBV DNA destabiliser - Arbutus Biopharma

Alternative Names: AB 452

Latest Information Update: 17 Apr 2018

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At a glance

  • Originator Enantigen Therapeutics
  • Developer Arbutus Biopharma
  • Class Antivirals; Small molecules
  • Mechanism of Action DNA-damage-stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Hepatitis B

Most Recent Events

  • 03 May 2018 Arbutus Biopharma plans clinical combination studies of AB 452 in Hepatitis B in 2019
  • 12 Apr 2018 Pharmacodynamics data from preclinical studies in Hepatitis B presented at the The International Liver Congress 2018 (ILC-2018)
  • 03 Oct 2017 Arbutus BioPharma intends to file an IND application/CTA or equivalent for AB 452 in Hepatitis B (PO) around mid-2018 to enable phase I study start
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