Vebreltinib - Apollomics/Beijing Pearl Biotechnology
Alternative Names: APL-101; Bozitinib - Apollomics/Beijing Pearl Biotechnology; Bozitinib - Beijing Pearl Biotechnology/CBT Pharmaceuticals; CBI-3103; CBT-101; PLB-1001Latest Information Update: 09 Jun 2025
At a glance
- Originator Crown Bioscience
- Developer Apollomics; Beijing Pearl Biotechnology
- Class Antineoplastics; Cyclopropanes; Fluorinated hydrocarbons; Indazoles; Pyrazoles; Pyridazines; Small molecules; Triazoles
- Mechanism of Action Proto-oncogene protein c-met inhibitors
-
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
- Available For Licensing Yes - Cancer
Highest Development Phases
- Registered Glioblastoma; Non-small cell lung cancer
- Phase II Solid tumours
- Phase I/II Liver cancer; Renal cell carcinoma
Most Recent Events
- 31 May 2025 Preregistration for Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in China (PO)
- 31 May 2025 Vebreltinib receives priority review status for Non-small cell lung cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in China (PO)
- 31 May 2025 Efficacy and adverse events data from a phase-I/II KYLIN-1 trial in Non-small cell lung cancer released by Avistone Pharmaceuticals