Drug Profile


Alternative Names: CBI-3103; CBT-101; PLB-1001

Latest Information Update: 05 Sep 2017

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At a glance

  • Originator Crown Bioscience
  • Developer Beijing Pearl Biotechnology; CBT Pharmaceuticals; Crown Bioscience
  • Class Antineoplastics; Small molecules
  • Mechanism of Action Proto oncogene protein c met inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity No

Highest Development Phases

  • Phase I Glioma; Non-small cell lung cancer; Solid tumours

Most Recent Events

  • 31 Aug 2017 Phase-I clinical trials in Solid tumours (Second-line therapy or greater, Metastatic disease) in USA (PO) (NCT03175224)
  • 14 Jun 2017 CBT Pharmaceuticals plans a phase I trial to evaluate the safety, pharmacokinetics and efficacy of CBT 101, in patients with Solid tumours (Late-stage disease) and c-MET dysregulation, in USA (PO, Capsule) (NCT03175224)
  • 04 Apr 2017 CBT Pharmaceuticals announces intention to submit IND application to US FDA for Solid tumours
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