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Zetomipzomib - Kezar Life Sciences

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Drug Profile

Zetomipzomib - Kezar Life Sciences

Alternative Names: KZR-616

Latest Information Update: 17 Nov 2025

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At a glance

  • Originator Onyx Pharmaceuticals
  • Developer Everest Medicines; Kezar Life Sciences
  • Class Anti-inflammatories; Antianaemics; Antirheumatics; Cyclopentanes; Hepatoprotectants; Morpholines; Small molecules; Urologics
  • Mechanism of Action Proteasome inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Dermatomyositis; Polymyositis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Autoimmune hepatitis; Dermatomyositis; Polymyositis; Systemic lupus erythematosus
  • Preclinical Haemophagocytic lymphohistiocytosis
  • Suspended Lupus nephritis
  • No development reported Autoimmune disorders

Most Recent Events

  • 10 Nov 2025 Efficacy data from a phase IIb PALIZADE trial in Lupus nephritis released by Kezar Life Sciences
  • 10 Nov 2025 Efficay and adverse events data from the phase IIa PORTOLA trial in Autoimmune hepatitis released by Kezar Life Sciences
  • 16 Oct 2025 US FDA cancels Type C meeting request with Kezar for the autoimmune hepatitis (AIH) development

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