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Zetomipzomib - Kezar Life Sciences

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Drug Profile

Zetomipzomib - Kezar Life Sciences

Alternative Names: KZR-616

Latest Information Update: 19 Jan 2026

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At a glance

  • Originator Onyx Pharmaceuticals
  • Developer Everest Medicines; Kezar Life Sciences
  • Class Anti-inflammatories; Antianaemics; Antirheumatics; Cyclopentanes; Hepatoprotectants; Morpholines; Small molecules; Urologics
  • Mechanism of Action Proteasome inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Polymyositis; Dermatomyositis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Autoimmune hepatitis; Dermatomyositis; Polymyositis; Systemic lupus erythematosus
  • Preclinical Haemophagocytic lymphohistiocytosis
  • Suspended Lupus nephritis
  • No development reported Autoimmune disorders

Most Recent Events

  • 09 Jan 2026 Kezar Life Sciences receives FDA agreement for a Type C meeting to discuss the development of Zetomipzomib in Autoimmune hepatitis (AIH)
  • 09 Jan 2026 Kezar Life Sciences plans a Type C meeting with the Division of Hepatology and Nutrition for Zetomipzomib in Autoimmune hepatitis (AIH) to discuss the clinical development pathway in the first quarter of 2026
  • 09 Jan 2026 Kezar Life Sciences plans to initiate a phase 2b clinical trial of Zetomipzomib in patients with relapsed and refractory Autoimmune hepatitis (AIH)

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