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Zetomipzomib - Kezar Life Sciences

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Drug Profile

Zetomipzomib - Kezar Life Sciences

Alternative Names: KZR-616

Latest Information Update: 21 Aug 2024

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At a glance

  • Originator Onyx Pharmaceuticals
  • Developer Everest Medicines; Kezar Life Sciences
  • Class Anti-inflammatories; Antianaemics; Antirheumatics; Cyclopentanes; Hepatoprotectants; Morpholines; Small molecules; Urologics
  • Mechanism of Action Proteasome inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Polymyositis; Dermatomyositis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Autoimmune hepatitis; Dermatomyositis; Lupus nephritis; Polymyositis; Systemic lupus erythematosus
  • Preclinical Haemophagocytic lymphohistiocytosis
  • No development reported Autoimmune disorders

Most Recent Events

  • 13 Aug 2024 Kezar Life Sciences completes enrolment in the phase-II PORTOLA trial in Autoimmune hepatitis in USA (SC) (NCT05569759)
  • 26 Feb 2024 NMPA approves IND application for zetomipzomib in Lupus nephritis
  • 26 Feb 2024 Everest Medicines and Kezar Life Sciences plans a phase IIb PALIZADE trial for Lupus nephritis in China

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