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BXQ 350

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Drug Profile

BXQ 350

Alternative Names: BXQ-350; SapC; SapC-DOPS; SapC-DOPS nanovesicles; Saposin C–dioleoylphosphatidylserine complexes; Sphingolipid activator protein C

Latest Information Update: 28 Jul 2026

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At a glance

  • Originator Bexion Pharmaceuticals
  • Developer Bexion Pharmaceuticals; Cincinnati Children's Hospital Medical Center
  • Class Antineoplastics; Antiparkinsonians; Phosphatidylserines; Saposins; Tumour-agnostic therapies
  • Mechanism of Action Sphingomyelin phosphodiesterase stimulants; Sphingosine 1-phosphate stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioma; Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Colorectal cancer; Glioblastoma; Glioma; Peripheral nervous system diseases
  • Phase 0 Peripheral neuropathies
  • Preclinical Parkinson's disease
  • No development reported CNS disorders; Solid tumours; Viral infections

Most Recent Events

  • 29 May 2026 Updated adverse events data from the phase Ib/IIa ASIST trial in Colorectal cancer presented at the 62nd Annual Meeting of the American Society of Clinical Oncology (ASCO-2026)
  • 22 Apr 2026 BXQ 350 is still in phase 0 trials for Peripheral neuropathies in USA (IV)
  • 22 Apr 2026 Efficacy data from a phase I/II ASIST trial in Colorectal cancer presented at the 117th Annual Meeting of the American Association for Cancer Research (AACR-2026)

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