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L-citrulline intravenous - Asklepion Pharmaceuticals/Vanderbilt-University

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Drug Profile

L-citrulline intravenous - Asklepion Pharmaceuticals/Vanderbilt-University

Alternative Names: L-citrulline; Turnobi

Latest Information Update: 06 Oct 2024

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At a glance

  • Originator Vanderbilt University
  • Developer Asklepion Pharmaceuticals; Vanderbilt University
  • Class Amino acids; Diamino amino acids; Small molecules
  • Mechanism of Action Amino acid replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute lung injury
  • New Molecular Entity No

Highest Development Phases

  • Phase III Acute lung injury
  • Phase II SARS-CoV-2 acute respiratory disease
  • Phase I/II Vaso-occlusive crisis

Most Recent Events

  • 13 Sep 2024 Asklepion Pharmaceuticals terminated a phase I/II clinical trials in Vaso-occlusive-crisis (In children, In adolescents, In adults) in USA (IV) due to impacted by viraemia resulting in higher than expected admissions (NCT04852172)
  • 28 May 2024 No recent reports of development identified for phase-I development in Vaso-occlusive-crisis in USA (IV, Injection)
  • 29 Jun 2022 Asklepion Pharmaceuticals initiates a phase III trial for Acute lung injury (Prevention, In infants, In children, In adolescents) in June 2022 (IV) (NCT05253209)

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