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Sintilimab - Eli Lilly and Company/Innovent Biologics

Drug Profile

Sintilimab - Eli Lilly and Company/Innovent Biologics

Alternative Names: Anti-PD-1 antibody - Eli Lilly and Company/Innovent Biologics; IBI-308; Sintilimab injection; Sintilimab injection - Eli Lilly and Company/Innovent Biologics; Tyvyt

Latest Information Update: 06 Sep 2021

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At a glance

  • Originator Adimab; Innovent Biologics
  • Developer Chinese Academy of Medical Sciences; Eli Lilly and Company; Innovent Biologics; Jiangsu Provincial Peoples Hospital; Peking University; Shanghai Jiaotong University School of Medicine; Sun Yat-Sen University; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Programmed cell death-1 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hodgkin's disease; Liver cancer; Non-small cell lung cancer
  • Phase III Acral lentiginous melanoma; Gastric cancer; Nasopharyngeal cancer; Oesophageal cancer
  • Phase II/III Colorectal cancer
  • Phase II Cancer; Cervical cancer; Extranodal NK-T-cell lymphoma; Small cell lung cancer
  • Phase I/II Solid tumours
  • Phase I Lung cancer; Lymphoma

Most Recent Events

  • 26 Aug 2021 Phase-II clinical trials in Cancer (Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV) (NCT05024968)
  • 24 Aug 2021 Innovent Biologics announces intention to submit sNDA to The National Medical Products Administration (NMPA) for Gastroesophageal Junction Adenocarcinoma
  • 05 Aug 2021 Registered for Liver cancer (Combination therapy, First-line therapy, Late-stage disease) in China (IV) before August 2021
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