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Sintilimab - Eli Lilly and Company/Innovent Biologics

Drug Profile

Sintilimab - Eli Lilly and Company/Innovent Biologics

Alternative Names: IBI-308; PD-1 antibody - Eli Lilly and Company/Innovent Biologics; Sintilimab injection - Eli Lilly and Company/Innovent Biologics; Tyvyt

Latest Information Update: 20 Jan 2020

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At a glance

  • Originator Adimab; Innovent Biologics
  • Developer Innovent Biologics; Jiangsu Provincial Peoples Hospital; Peking University; Shanghai Jiaotong University School of Medicine; Sun Yat-Sen University; Tianjin Medical University Cancer Institute and Hospital
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Programmed cell death-1 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hodgkin's disease
  • Phase III Gastric cancer; Nasopharyngeal cancer; Non-small cell lung cancer; Oesophageal cancer
  • Phase II/III Liver cancer
  • Phase II Extranodal NK-T-cell lymphoma; Small cell lung cancer
  • Phase I/II Solid tumours

Most Recent Events

  • 12 Jan 2020 Innovent and Eli Lilly intends to initiate a regulatory discussions for registration with the National Medical Products Administration (NMPA) in China
  • 12 Jan 2020 Interim efficacy data from a phase III ORIENT-11 trial in Non small cell lung cancer released by Innovent Biologics
  • 07 Jan 2020 Innovent and Sirnaomics enter into a strategic collaboration for a clinical trial for Hepatocellular carcinoma and cholangiocarcinoma
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