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Crovalimab - Chugai Pharmaceutical/Roche

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Drug Profile

Crovalimab - Chugai Pharmaceutical/Roche

Alternative Names: Anti-C5 recycling antibody - Chugai Pharmaceutical/Roche; CH-7092230; Crovalimab-akkz; Piasky; RG 6107; RO 7092230; RO-7112689; RO-711269; RO7112689/F01; SKY-59

Latest Information Update: 11 Mar 2026

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At a glance

  • Originator Chugai Pharmaceutical
  • Developer Chugai Pharmaceutical; Roche
  • Class Antianaemics; Monoclonal antibodies; Urologics
  • Mechanism of Action Complement C5 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Paroxysmal nocturnal haemoglobinuria
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Paroxysmal nocturnal haemoglobinuria
  • Phase III Atypical Haemolytic Uraemic Syndrome
  • Discontinued Lupus nephritis; Sickle cell anaemia

Most Recent Events

  • 02 Mar 2026 Roche withdraws a phase-II trial in Antiphospholipid Syndrome (Treatment experienced) prior to enrolment due to strategic portfolio business decision by the sponsor (SC) (NCT07172022)
  • 28 Oct 2025 No recent reports of development identified for phase-I development in Sickle-cell-anaemia(In adolescents, In adults) in Kenya (IV, Infusion)
  • 28 Oct 2025 No recent reports of development identified for phase-I development in Sickle-cell-anaemia(In adolescents, In adults) in Lebanon (IV, Infusion)

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