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Ezabenlimab - Boehringer Ingelheim

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Drug Profile

Ezabenlimab - Boehringer Ingelheim

Alternative Names: BI-754091

Latest Information Update: 22 Apr 2024

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At a glance

  • Originator Boehringer Ingelheim
  • Developer Amal Therapeutics; Boehringer Ingelheim; National Health Research Institutes
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; Programmed cell death 1 receptor antagonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Anal cancer; Oesophageal cancer; Solid tumours; Squamous cell cancer
  • Phase I/II Colorectal cancer
  • Phase I Adenocarcinoma; Liver cancer; Neuroendocrine tumours; Small cell lung cancer
  • No development reported Head and neck cancer; Non-small cell lung cancer

Most Recent Events

  • 22 Apr 2024 Boehringer Ingelheim plans a phase III Brightline-3 trial for Soft tissue sarcoma (Late-stage disease, Monotherapy, Combination therapy, Second-line therapy or greater) (PO), in June 2024 (NCT06370871)
  • 31 Jan 2024 Boehringer Ingelheim initiates enrolment in a phase I trial for Solid tumours (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease) in Japan (NCT06091930) (IV)
  • 18 Jan 2024 Efficacy and adverse events data from the phase II INTERACT-ION trial in Anal cancer presented at the Gastrointestinal Cancers Symposium ASCO-GCS-2024)

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