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Alrizomadlin - Ascentage Pharma

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Drug Profile

Alrizomadlin - Ascentage Pharma

Alternative Names: APG-115

Latest Information Update: 08 Jun 2026

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At a glance

  • Originator Ascentage Pharma
  • Developer Ascentage Pharma; Suzhou Yasheng Pharmaceutical; University of Michigan
  • Class Amides; Antineoplastics; Chlorobenzenes; Fluorobenzenes; Pyrrolidines; Small molecules; Spiro compounds
  • Mechanism of Action Apoptosis stimulants; Proto-oncogene protein c-mdm2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Soft tissue sarcoma; Retinoblastoma; Gastric cancer; Acute myeloid leukaemia; Malignant melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Malignant melanoma; Solid tumours; T-cell prolymphocytic leukaemia
  • Phase I/II Acute myeloid leukaemia; Liposarcoma; Salivary gland cancer
  • Phase I Neuroblastoma
  • Preclinical Uveal melanoma
  • No development reported Dry age-related macular degeneration; Gastric cancer; Lymphoma; Multiple myeloma; Myelodysplastic syndromes

Most Recent Events

  • 08 Jun 2026 Alrizomadlin is still in phase-I development in Neuroblastoma (Monotherapy, Combination therapy, In adolescents, Recurrent, Second-line therapy or greater) and Solid-tumours (Monotherapy, Combination therapy, In adolescents, Recurrent, Second-line therapy or greater) in China (PO) (NCT05701306)
  • 01 Jun 2026 Efficacy and adverse event data from a phase I trial in Solid tumour released by Ascentage Pharma Group
  • 29 May 2026 Efficacy and advers event data data from phase I trial in Solid tumours presented at the 62nd Annual Meeting of the American Society of Clinical Oncology 2026 (ASCO-2026)

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