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Alrizomadlin - Ascentage Pharma

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Drug Profile

Alrizomadlin - Ascentage Pharma

Alternative Names: APG-115

Latest Information Update: 16 Apr 2024

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At a glance

  • Originator Ascentage Pharma
  • Developer Ascentage Pharma; Suzhou Yasheng Pharmaceutical; University of Michigan
  • Class Amides; Antineoplastics; Chlorobenzenes; Fluorobenzenes; Pyrrolidines; Small molecules; Spiro compounds
  • Mechanism of Action Apoptosis stimulants; Proto-oncogene protein c-mdm2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastric cancer; Malignant melanoma; Soft tissue sarcoma; Retinoblastoma; Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Malignant melanoma; Solid tumours; T-cell prolymphocytic leukaemia
  • Phase I/II Acute myeloid leukaemia; Liposarcoma; Salivary gland cancer
  • Phase I Myelodysplastic syndromes; Neuroblastoma
  • Preclinical Dry age-related macular degeneration; Multiple myeloma; Uveal melanoma
  • No development reported Gastric cancer; Lymphoma

Most Recent Events

  • 07 Apr 2024 Pharmacodynamics data from a preclinical trial in Prostate cancer released by Ascentage Pharma
  • 05 Mar 2024 Pharmacodynamics data from a preclinical study in Prostate cancer released by Ascentage Pharma
  • 01 Mar 2024 Ascentage Pharma Group terminates a phase-I/II trial in Salivary gland cancer (Second-line therapy or greater, Combination therapy, Monotherapy) in USA (PO) as enrollment has been placed on hold due to pending evaluability assessment (NCT03781986)

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