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Bomedemstat - Imago BioSciences

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Drug Profile

Bomedemstat - Imago BioSciences

Alternative Names: Bomedemstat tosylate - Imago BioSciences; IMG-241 bis-tosylate salt; IMG-7289; LSD1 inhibitor - Imago BioSciences; MK-3543

Latest Information Update: 26 Mar 2025

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At a glance

  • Originator Imago BioSciences
  • Developer Imago BioSciences; University of Hong Kong
  • Class Amides; Amines; Antihaemorrhagics; Antineoplastics; Benzamides; Benzene derivatives; Cyclopropanes; Fluorobenzenes; Piperazines; Small molecules; Triazoles
  • Mechanism of Action Lysine specific demethylase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Myelofibrosis; Essential thrombocythaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Essential thrombocythaemia; Polycythaemia vera
  • Phase II Acute myeloid leukaemia; Myelodysplastic syndromes; Myelofibrosis
  • Phase I/II Small cell lung cancer

Most Recent Events

  • 11 Mar 2025 Merck Sharp & Dohme completes a phase I Drug-Drug Interaction trial (In volunteers) in USA (PO, Tablet) (NCT06596668)
  • 12 Dec 2024 Imago BioSciences suspends phase I VenBom trial in Acute myeloid leukaemia (Combination therapy, Refractory metastatic disease, Second-line therapy or greater) in USA (PO), due to drug availability (NCT05597306)
  • 07 Dec 2024 Pharmacodynamics data from a preclinical studies in myeloproliferative disorders presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-2024)

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