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Botulinum toxin E - AbbVie

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Drug Profile

Botulinum toxin E - AbbVie

Alternative Names: AGN 151586; BoNT/E; BoNTE; EB-001; EB-001A; EB-001T; TrenibotE; TrenibotulinumtoxinE

Latest Information Update: 02 May 2025

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At a glance

  • Originator Bonti
  • Developer AbbVie
  • Class Antispasmodics; Bacterial proteins; Bacterial toxins; Botulinum toxins; Muscle relaxants; Recombinant proteins; Skin disorder therapies
  • Mechanism of Action Acetylcholine inhibitors; Glutamate antagonists; Neuromuscular blocking agents; SNARE protein antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Glabellar lines
  • Discontinued Musculoskeletal pain; Scars

Most Recent Events

  • 24 Apr 2025 Preregistration for Glabellar lines in USA (IM)
  • 26 Feb 2025 AbbVie completes phase III clinical trials in Glabellar lines in Japan, China and Taiwan (IM) (NCT06308198)
  • 18 Feb 2025 AbbVie initiates enrolment in a phase I trial for Glabellar lines in US (IM) (NCT06834789)

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