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VS 01

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Drug Profile

VS 01

Alternative Names: VS-01; VS-01-HAC

Latest Information Update: 28 May 2025

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At a glance

  • Originator Genfit; Versantis
  • Class Drug withdrawal therapies; Tricarboxylic acids
  • Mechanism of Action Ammonia scavengers
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Inborn urea cycle disorders; Liver failure; Hyperammonaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Hepatic encephalopathy; Liver failure
  • Preclinical Hyperammonaemia; Inborn urea cycle disorders; Substance-related disorders

Most Recent Events

  • 23 May 2025 Versantis AG plans a phase II trial for Hepatic encephalopathy and Liver Failure in June 2025 (NCT06987968)
  • 24 Apr 2025 Genfit plans a first-in-human pediatric trial toward the end of 2026
  • 24 Apr 2025 Genfit plans a pivotal juvenile toxicology study in Göttingen Minipigs as early as second half of 2025

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