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Sotuletinib - Celgene Corporation/Novartis

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Drug Profile

Sotuletinib - Celgene Corporation/Novartis

Alternative Names: BLZ-945

Latest Information Update: 18 Dec 2024

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At a glance

  • Originator Celgene Corporation; Novartis
  • Class Amides; Amines; Antineoplastics; Benzothiazoles; Cyclohexanols; Ethers; Pyridines; Small molecules
  • Mechanism of Action Macrophage colony-stimulating factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Amyotrophic lateral sclerosis
  • Phase I/II Solid tumours
  • No development reported Bone disorders

Most Recent Events

  • 23 Oct 2024 Pharmacodynamics data from preclinical studies in Triple negative breast cancer presented at the 36th EORTC-NCI-AACR Symposium on molecular targets and cancer therapeutics
  • 09 Aug 2024 Novartis terminates a Phase-II clinical trials in Amyotrophic lateral sclerosis in US, Sweden, Australia and Finland assessment of potential benefit-risk from available data (EudraCT2019-000826-22) (NCT04066244)
  • 05 Apr 2024 Pharmacodynamics data from a phase I/II trial in Solid tumours presented at the 115th Annual Meeting of the American Association for Cancer Research (AACR-2024)

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