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Belzutifan - Merck & Co

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Drug Profile

Belzutifan - Merck & Co

Alternative Names: MK 6482; PT-2977; WELIREG; WELIREGTM

Latest Information Update: 30 Apr 2026

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At a glance

  • Originator Peloton Therapeutics
  • Developer Eisai Inc; Merck & Co; Merck Sharp & Dohme; Peloton Therapeutics
  • Class Antineoplastics; Benzonitrile; Fluorobenzenes; Indenes; Small molecules; Sulfones
  • Mechanism of Action Endothelial PAS domain-containing protein 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Von Hippel-Lindau disease
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Paraganglioma; Phaeochromocytoma; Renal cell carcinoma; Von Hippel-Lindau disease
  • Preregistration Neuroendocrine tumours
  • Phase III Solid tumours
  • Phase II Gastrointestinal stromal tumours; HER2 negative breast cancer
  • Phase I/II Prostate cancer
  • Discontinued Iron overload

Most Recent Events

  • 21 Apr 2026 Interim adverse events and efficacy data from a phase III LITESPARK-012 trial in Renal cell carcinoma released by Merck & Co
  • 09 Apr 2026 Phase-III clinical trials in Renal cell carcinoma (Second-line therapy or greater, Inoperable/Unresectable, Late-stage disease, Combination therapy) in South Korea (PO) (NCT07489495)
  • 09 Apr 2026 Merck initiates enrolment in a phase III trial in Renal cell carcinoma (Second-line therapy or greater, Inoperable/Unresectable, Late-stage disease, Combination therapy) in South Korea (PO) (NCT07489495)

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