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Belzutifan - Merck & Co

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Drug Profile

Belzutifan - Merck & Co

Alternative Names: MK 6482; PT-2977; WELIREG; WELIREGTM

Latest Information Update: 30 Jun 2025

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At a glance

  • Originator Peloton Therapeutics
  • Developer Eisai Inc; Merck & Co; Merck Sharp & Dohme; Peloton Therapeutics
  • Class Antineoplastics; Benzonitrile; Fluorobenzenes; Indenes; Small molecules; Sulfones
  • Mechanism of Action Endothelial PAS domain-containing protein 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Von Hippel-Lindau disease
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Renal cell carcinoma; Von Hippel-Lindau disease
  • Preregistration Neuroendocrine tumours
  • Phase II Gastrointestinal stromal tumours; HER2 negative breast cancer; Phaeochromocytoma; Solid tumours
  • Phase I/II Prostate cancer
  • Discontinued Iron overload

Most Recent Events

  • 27 May 2025 Merck Sharp & Dohme completes a phase I pharmacokinetic trial (In volunteers) in USA (PO) (NCT06903715)
  • 28 Mar 2025 Merck Sharp & Dohme initiates a phase I pharmacokinetic trial (In volunteers) in USA (PO) (NCT06903715)
  • 26 Mar 2025 Merck Sharp & Dohme plans a phase I pharmacokinetic trial (In volunteers) in March 2025 (NCT06903715)

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