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Belzutifan - Peloton Therapeutics

Drug Profile

Belzutifan - Peloton Therapeutics

Alternative Names: MK 6482; PT-2977; WELIREG; WELIREGTM

Latest Information Update: 13 Jul 2024

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At a glance

  • Originator Peloton Therapeutics
  • Developer Eisai Inc; Merck & Co; Merck Sharp & Dohme; Peloton Therapeutics
  • Class Antineoplastics; Benzonitrile; Fluorobenzenes; Indenes; Small molecules; Sulfones
  • Mechanism of Action Endothelial PAS domain-containing protein 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Von Hippel-Lindau disease
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Renal cell carcinoma; Von Hippel-Lindau disease
  • Phase II Neuroendocrine tumours; Solid tumours
  • Phase I/II Prostate cancer
  • Discontinued Iron overload

Most Recent Events

  • 31 May 2024 Efficacy, adverse events and pharmacokinetics data from a phase I trial in Renal cell carcinoma presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
  • 31 May 2024 Efficacy and adverse events data from phase I/II LITESPARK-001 trial in Renal cell carcinoma presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)
  • 24 May 2024 Merck Sharp & Dohme plans a phase II trial for HER2-negative-breast-cancer (Metastatic disease, Second-line therapy or greater, Combination therapy) (PO, Tablet) (NCT06428396)
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