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AGEN 1949

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Drug Profile

AGEN 1949

Alternative Names: AGEN-1949; Anti-OX40-monoclonal-antibody- Incyte Corporation; INCAGN-01949; INCAGN-1949

Latest Information Update: 25 Feb 2026

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At a glance

  • Originator Agenus; Ludwig Institute for Cancer Research
  • Developer Agenus; Incyte Corporation
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; OX40 receptor agonists; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours
  • Discontinued Pancreatic cancer

Most Recent Events

  • 16 Feb 2026 Incyte Corporation terminates licensing agreement with Agenus
  • 27 Jan 2026 Phase-I clinical trials in Solid tumours (Monotherapy) (IV), prior to January 2026 (Agenus pipeline, January 2026)
  • 20 Feb 2023 Discontinued - Phase-I for Pancreatic cancer in USA (Parenteral) prior to February 2023 (Agenus website, February 2023)

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