RGLS 4326

Drug Profile

RGLS 4326

Alternative Names: RGLS-4326

Latest Information Update: 20 Jul 2018

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At a glance

  • Originator Regulus Therapeutics
  • Class Antisense oligonucleotides; MicroRNAs
  • Mechanism of Action MicroRNA inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Autosomal dominant polycystic kidney disease

Most Recent Events

  • 05 Jul 2018 Regulus Therapeutics halts phase I multiple ascending dose (MAD) study due to unexpected observations in its 27-week mouse chronic toxicity study
  • 10 May 2018 Regulus Therapeutics plans a phase II proof-of-concept trial for Autosomal-dominant polycystic kidney disease in USA
  • 10 May 2018 Regulus Therapeutics initiates enrolment in a phase I MAD trial for Autosomal-dominant polycystic kidney disease (in healthy volunteers) in USA (SC)
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