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RGLS 4326

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Drug Profile

RGLS 4326

Alternative Names: RGLS-4326

Latest Information Update: 01 Jul 2025

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At a glance

  • Originator Regulus Therapeutics
  • Developer Novartis
  • Class Antisense oligonucleotides; MicroRNAs
  • Mechanism of Action MIRN17 microRNA inhibitors; RNA interference
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Autosomal dominant polycystic kidney disease
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Autosomal dominant polycystic kidney disease

Most Recent Events

  • 25 Jun 2025 Regulus Therapeutics has been acquired and merged into Novartis
  • 07 Nov 2024 Pharmacodynamics data from a preclinical trial in Autosomal dominant polycystic kidney disease released by Regulus Therapeutics
  • 12 Nov 2021 Regulus Therapeutics completes a phase I trial in Autosomal dominant polycystic kidney disease (In adults, In the elderly) in USA (SC) (NCT04536688)

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