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Vonafexor - ENYO Pharma

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Drug Profile

Vonafexor - ENYO Pharma

Alternative Names: EYP 001; EYP001a; PXL 007

Latest Information Update: 30 Apr 2025

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At a glance

  • Originator Poxel
  • Developer ENYO Pharma; Poxel; PRA Health Sciences
  • Class Antivirals; Benzopyrans; Carboxylic acids; Chlorobenzenes; Hepatoprotectants; Piperazines; Small molecules; Sulfones
  • Mechanism of Action Farnesoid X-activated receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hereditary nephritis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Hepatitis B; Hereditary nephritis; Kidney disorders; Non-alcoholic steatohepatitis

Most Recent Events

  • 23 Apr 2025 Enyo Pharma plans phase-II trial for Kidney disorders and Non-alcoholic steatohepatitis in Germany (PO, Tablet) in July 2025 (NCT06939816)
  • 06 Jun 2024 Phase-II clinical trials in Hereditary nephritis (In adolescents, In adults) in USA (PO) (NCT06425055)
  • 16 Jan 2024 Phase-II clinical trials in Kidney disorders (unspecified route) (Enyo Pharma pipeline, January 2023)

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