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R 21

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Drug Profile

R 21

Alternative Names: Malaria virus-like particle vaccine - MultiMalVax; Matrix-M; Plasmodium falciparum circumsporozoite protein/HBsAg subunit vaccine - Multimalvax; R-21; R21/Matrix-M; R21/Matrix-M adjuvanted malaria vaccine; R21/Matrix-M™ malaria vaccine; R21/MM

Latest Information Update: 06 Sep 2025

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At a glance

  • Originator University of Oxford
  • Developer GSK; Serum Institute of India; University of Oxford
  • Class Antimalarials; Malaria vaccines; Parasitic vaccines; Subunit vaccines; Virus-like particle vaccines
  • Mechanism of Action Immunostimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Registered Falciparum malaria

Most Recent Events

  • 31 Aug 2025 Serum Institute of India plans to initiate phase II trial in Malaria (Prevention, In children, In adolescents, In adults in Mali (IM) (NCT07147400)
  • 22 Aug 2025 Phase-II clinical trials in Falciparum malaria (Combination therapy, Prevention, In children, In adolescents, In adults) in Mali (IM) (NCT07147400)
  • 22 Aug 2025 Phase-II clinical trials in Falciparum malaria (Prevention, In children, In adolescents, In adults, Monotherapy) in Mali (IM) (NCT07147400)

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