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Inavolisib - Genentech

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Drug Profile

Inavolisib - Genentech

Alternative Names: GDC 0077; RG 6114; RO-7113755

Latest Information Update: 16 Aug 2024

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At a glance

  • Originator Genentech
  • Developer Genentech; Roche
  • Class Amides; Amines; Antineoplastics; Aza compounds; Benzene derivatives; Fluorinated hydrocarbons; Imidazoles; Small molecules
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration HER2 negative breast cancer
  • Phase III HER2 positive breast cancer
  • Phase II Breast cancer; Ovarian cancer; Solid tumours
  • Phase I Colorectal cancer; Squamous cell cancer

Most Recent Events

  • 16 Aug 2024 Preregistration for HER2-negative-breast-cancer (Combination therapy, First-line therapy, Late-stage disease, Metastatic disease) in European Union (PO) (Roche pipeline, August 2024)
  • 05 Jul 2024 Roche completes a Phase I trial in Solid tumours (Metastatic disease, Second-line therapy or greater) in Romania, Moldova (PO) (ISRCTN12839469)
  • 31 May 2024 Adverse events and efficacy data from phase III INAVO120 trials in Breast cancer presented at the 60th Annual Meeting of the American Society of Clinical Oncology (ASCO-2024)

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