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TRE 515

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Drug Profile

TRE 515

Alternative Names: DI-87; TRE-515

Latest Information Update: 24 Dec 2025

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At a glance

  • Originator University of California at Los Angeles
  • Developer Harvard University; Stanford University; Trethera; University of California at Los Angeles
  • Class Anti-inflammatories; Antineoplastics; Diamines; Eye disorder therapies; Morpholines; Pyrimidines; Small molecules; Thiazoles
  • Mechanism of Action Deoxycytidine Kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Optic neuritis; Acute disseminated encephalomyelitis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I Solid tumours
  • Clinical Phase Unknown Amyotrophic lateral sclerosis
  • Preclinical Crohn's disease; Multiple sclerosis; Non-small cell lung cancer; Optic neuritis; Systemic lupus erythematosus

Most Recent Events

  • 16 Dec 2025 Trethera receives SBIR grant from the National Institutes of Health (NIH) for TRE 515 development in Non-small cell lung cancer
  • 16 Dec 2025 Preclinical trials in Non-small cell lung cancer in USA (PO)
  • 23 Sep 2025 Preclinical trials in Crohn's disease in USA (PO)

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