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Olverembatinib - Ascentage Pharma

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Drug Profile

Olverembatinib - Ascentage Pharma

Alternative Names: APG 1351; BCR-ABL TKI; D 824; GZD 824; HQP 1351; IBI-348; Orebatinib

Latest Information Update: 18 Dec 2024

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At a glance

  • Originator Guangzhou Institutes of Biomedicine and Health
  • Developer Ascentage Pharma; Innovent Biologics
  • Class Antineoplastics; Benzamides; Fluorinated hydrocarbons; Piperazines; Pyrazoles; Pyridines; Small molecules
  • Mechanism of Action Bcr-Abl tyrosine kinase inhibitors; Cytokine inhibitors; Fms-like tyrosine kinase 3 inhibitors; Proto-oncogene protein c-kit inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastrointestinal stromal tumours; Chronic myeloid leukaemia; Acute myeloid leukaemia; Precursor cell lymphoblastic leukaemia-lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Chronic myeloid leukaemia
  • Registered Acute myeloid leukaemia
  • Phase III Precursor cell lymphoblastic leukaemia-lymphoma
  • Phase I/II Gastrointestinal stromal tumours; Solid tumours
  • Preclinical COVID 2019 infections; Renal cell carcinoma

Most Recent Events

  • 10 Dec 2024 Efficacy and adverse events data from phase II trial for Chronic myeloid leukaemia released by Ascentage Pharma
  • 21 Nov 2024 Efficacy and adverse events data from a phase I trial in Chronic myeloid leukaemia and Precursor cell lymphoblastic leukaemia-lymphoma released byAscentage Pharma
  • 06 Nov 2024 Efficacy and adverse events data phase Ib trial in Chronic myeloid leukemia released by Ascentage , ,

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