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Anselamimab - Caelum Biosciences

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Drug Profile

Anselamimab - Caelum Biosciences

Alternative Names: 11-1F4; CAEL-101; Ch mAb 11-1F4; Chimeric fibril reactive monoclonal antibody 11-1F4 -Caelum Biosciences; Fibril-reactive monoclonal antibody 11-1F4; mAb 11-1F4

Latest Information Update: 17 Feb 2026

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At a glance

  • Originator Columbia University
  • Developer Alexion AstraZeneca Rare Disease; Caelum Biosciences
  • Class Monoclonal antibodies
  • Mechanism of Action Serum amyloid A protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Amyloidosis; Amyloid light-chain amyloidosis
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Preregistration Amyloid light-chain amyloidosis

Most Recent Events

  • 12 Feb 2026 Preregistration for Amyloid light-chain amyloidosis (Combination therapy, Treatment-naive) in Japan (IV)
  • 12 Feb 2026 Preregistration for Amyloid light-chain amyloidosis (Treatment-naive, Combination therapy) in European Union (IV)
  • 16 Jul 2025 Efficacy data from a phase III CARES trial in amyloid light-chain amyloidosis released by AstraZeneca

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