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Dapolsertib - Menarini

Drug Profile

Dapolsertib - Menarini

Alternative Names: MEN 1703; MEN1703/SEL24; SEL 24; SEL24 program; SEL24-1; SEL24-B489; SEL24/MEN1703

Latest Information Update: 06 May 2025

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At a glance

  • Originator Selvita
  • Developer Menarini; Ryvu Therapeutics; Theradex
  • Class Antineoplastics; Benzimidazoles; Halogenated hydrocarbons; Nitro compounds; Small molecules
  • Mechanism of Action Fms-like tyrosine kinase 3 inhibitors; Proto oncogene protein c pim 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia; B-cell lymphoma; Diffuse large B cell lymphoma
  • Preclinical Myelofibrosis

Most Recent Events

  • 25 Apr 2025 Phase-II clinical trials in Diffuse large B cell lymphoma (Combination therapy, Second-line therapy or greater) in France (PO) (NCT06534437) (Ryvu Therapeutics pipeline, May 2025)
  • 25 Apr 2025 Phase-II clinical trials in Diffuse large B cell lymphoma (Combination therapy, Second-line therapy or greater) in Spain (PO) (NCT06534437) (Ryvu Therapeutics pipeline, May 2025)
  • 25 Apr 2025 Phase-II clinical trials in Diffuse large B cell lymphoma (Second-line therapy or greater, Monotherapy) in France (PO) (NCT06534437) (Ryvu Therapeutics pipeline, May 2025)

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