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Zegocractin - CalciMedica

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Drug Profile

Zegocractin - CalciMedica

Alternative Names: Auxora; CM-4620; CM4620-IE

Latest Information Update: 29 Aug 2025

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At a glance

  • Originator CalciMedica
  • Class Anti-inflammatories; Antivirals; Benzamides; Chlorobenzenes; Dioxoles; Fluorobenzenes; Pyrazines; Small molecules; Urologics
  • Mechanism of Action ORAI1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatitis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III COVID-19 pneumonia
  • Phase II Acute kidney injury; Pancreatitis; SARS-CoV-2 acute respiratory disease; Systemic inflammatory response syndrome
  • Preclinical Inflammatory bowel diseases; Renal failure; Respiratory distress syndrome

Most Recent Events

  • 12 Aug 2025 CalciMedica plans to meet with USFDA for Acute pancreatitis in second half of 2025
  • 11 Jul 2025 Efficacy data from a phase II CARDEA trial for Covid-19 pneumonia presented at the Thrombosis Update
  • 30 Oct 2024 Efficacy and adverse event data from the phase II CARPO tiral in Systemic inflammatory response syndrome and Pancreatitis released by CalciMedica

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