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Zegocractin - CalciMedica

Drug Profile

Zegocractin - CalciMedica

Alternative Names: Auxora; CM-4620; CM4620-IE

Latest Information Update: 21 May 2024

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At a glance

  • Originator CalciMedica
  • Class Anti-inflammatories; Antivirals; Benzamides; Chlorobenzenes; Dioxoles; Fluorobenzenes; Pyrazines; Small molecules
  • Mechanism of Action Immunosuppressants; ORAI1 protein inhibitors; STIM1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatitis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III COVID-19 pneumonia
  • Phase II Pancreatitis; SARS-CoV-2 acute respiratory disease; Systemic inflammatory response syndrome
  • Preclinical Acute kidney injury; Inflammatory bowel diseases; Renal failure; Respiratory distress syndrome

Most Recent Events

  • 13 May 2024 CalciMedica completes enrolment in its phase II trial for Systemic inflammatory response syndrome in USA and India (IV)
  • 25 Apr 2024 CalciMedica completes enrolment in its phase IIb CARPO trial for acute pancreatitis in US and India
  • 28 Mar 2024 CalciMedica has patent protection for Zegocractin Worldwide
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