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Tegavivint - Apollomics/Iterion Therapeutics

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Drug Profile

Tegavivint - Apollomics/Iterion Therapeutics

Alternative Names: APL-121; BC-2059; Tegatrabetan - Iterion therapeutics

Latest Information Update: 28 Nov 2024

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At a glance

  • Originator BetaCat Pharmaceuticals
  • Developer Apollomics; Iterion Therapeutics; M. D. Anderson Cancer Center; Ohio State University Comprehensive Cancer Center
  • Class Anthracenes; Antineoplastics; Hydroxylamines; Nitroso compounds; Piperidines; Small molecules; Sulfonamides
  • Mechanism of Action Beta catenin inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Fibroma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Fibroma
  • Phase I/II Liver cancer; Solid tumours
  • Phase I B-cell lymphoma; Non-small cell lung cancer
  • Preclinical Acute myeloid leukaemia; Lymphoma; Osteosarcoma
  • No development reported Multiple myeloma

Most Recent Events

  • 28 Nov 2024 No recent reports of development identified for phase-I development in Acute-myeloid-leukaemia(Combination therapy, Recurrent, Second-line therapy or greater) in USA (IV)
  • 28 Nov 2024 No recent reports of development identified for phase-I development in Acute-myeloid-leukaemia(Monotherapy, Recurrent, Second-line therapy or greater) in USA (IV)
  • 13 Sep 2023 Phase-I/II clinical trials in Liver cancer (Late-stage disease, Second-line therapy or greater, Combination therapy) in Canada, USA (IV) (NCT05797805)

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