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Zagociguat - Cyclerion Therapeutics

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Drug Profile

Zagociguat - Cyclerion Therapeutics

Alternative Names: CY-6463; IW-6463

Latest Information Update: 15 Jan 2026

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At a glance

  • Originator Ironwood Pharmaceuticals
  • Developer Cyclerion Therapeutics; Tisento Therapeutics
  • Class Antidementias; Antipsychotics; Nootropics; Small molecules
  • Mechanism of Action Soluble guanylyl cyclase agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Mitochondrial disorders
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease; MELAS syndrome; Mitochondrial disorders
  • No development reported Dementia; Schizophrenia

Most Recent Events

  • 08 Jan 2026 Tisento Therapeutics completes enrolment in its phase-II clinical trials in MELAS syndrome in US, Germany, Australia, Canada, Italy, United Kingdom (PO) (NCT06402123)
  • 02 Sep 2025 Chemical structure information added.
  • 20 Aug 2025 Phase-II clinical trials in MELAS syndrome (Treatment-experienced) in USA (PO) (NCT06961344)

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