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BRM 421

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Drug Profile

BRM 421

Alternative Names: BRM 421; GPN 00136; PDSP

Latest Information Update: 26 Feb 2026

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At a glance

  • Originator MacKay Memorial Hospital
  • Developer BRIM Biotechnology
  • Class Peptides
  • Mechanism of Action Cell proliferation stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Dry eyes
  • Clinical Phase Unknown Limbal stem cell deficiency
  • Preclinical Osteoarthritis
  • No development reported Alopecia; Corneal injuries

Most Recent Events

  • 20 Feb 2026 Clinical trial in Limbal stem cell deficiency in USA (Ophthalmic) (NCT07422389)
  • 24 Jul 2025 BRIM Biotechnology plans phase II trial in Dry Eyes in Taiwan in November 2025 (NCT07078955)
  • 04 Dec 2024 BRIM Biotechnology plans a phase I trial for Osteoarthritis (Intra-articular, Injection) in 2025 (BRIM Biotechnology pipeline, December 2024)

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