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Orvacabtagene autoleucel - Juno Therapeutics

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Drug Profile

Orvacabtagene autoleucel - Juno Therapeutics

Alternative Names: Anti BCMA CAR T cell therapy - Juno Therapeutics; Anti-BCMA CAR - Juno Therapeutics; Anti-BMCA Chimeric antigen receptor cell therapy-Juno Therapeutics; BCMA-CAR-T-Juno Therapeutics; BCMA-specific CAR expressing T-Lymphocytes-Juno Therapeutics; BCMA-specific CAR-T-Juno Therapeutics; BCMA-Targeted CAR-T Cells-Juno Therapeutics; JCARH-125; orva-cel

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Fred Hutchinson Cancer Research Center; Memorial Sloan-Kettering Cancer Center
  • Class Antineoplastics; CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma
  • New Molecular Entity No

Highest Development Phases

  • Phase I/II Multiple myeloma

Most Recent Events

  • 04 Jun 2021 Updated efficacy and adverse events data from the phase I/II EVOLVE trial in Multiple myeloma presented at the 57th Annual Meeting of the American Society of Clinical Oncology (ASCO-2021)
  • 29 May 2020 Efficacy and adverse events data from the phase I/II EVOLVE trial in Multiple myeloma presented at 56th Annual Meeting of the American Society of Clinical Oncology (ASCO-2020)
  • 03 Dec 2018 Interim adverse events and efficacy data from phase I/II Evolve trial in Multiple myeloma presented at the 60th American Society of Hematology Annual Meeting (ASH-Hem-2018)

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