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Doxycycline hyclate controlled release - POLYPID

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Drug Profile

Doxycycline hyclate controlled release - POLYPID

Alternative Names: D-PLEX; D-PLEX-100; Doxycycline/polymer-lipid encapsulation matrix; PLEX-doxycycline

Latest Information Update: 28 Aug 2025

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At a glance

  • Originator POLYPID
  • Class Antibacterials; Collagenases; Skin disorder therapies; Tetracyclines
  • Mechanism of Action Protein 30S ribosomal subunit inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase III Surgical wound infections

Most Recent Events

  • 13 Aug 2025 Adverse events data from a phase III SHIELD II trial in Surgical wound infections released by POLYPID
  • 09 Jun 2025 Efficacy data from the phase III SHIELD II trial in Surgical wound infections released by POLYPID
  • 14 May 2025 PolyPid plans to submit a New Drug Application (NDA) to the US Food and Drug Administration (FDA) for Surgical wound infections (Prevention) in early 2026

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