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Rezpegaldesleukin - Nektar Therapeutics

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Drug Profile

Rezpegaldesleukin - Nektar Therapeutics

Alternative Names: IL-2 conjugate; Interleukin-2 conjugate; LY-3471851; NKTR-358; PEG-conjugated rhIL-2; REZPEG - Nektar Therapeutics

Latest Information Update: 19 Dec 2025

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At a glance

  • Originator Nektar Therapeutics
  • Developer Eli Lilly and Company; Nektar Therapeutics
  • Class Anti-inflammatories; Antipsoriatics; Interleukins; Polyethylene glycols; Recombinant proteins; Skin disorder therapies
  • Mechanism of Action Interleukin 2 modulators; Regulatory T-lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alopecia areata; Atopic dermatitis; Systemic lupus erythematosus
  • Discontinued Psoriasis; Ulcerative colitis

Most Recent Events

  • 17 Dec 2025 Efficacy, pharmacokinetics and adverse events data from a phase II REZOLVE-AA trial in Alopecia areata released by Nektar Therapeutics
  • 16 Dec 2025 Nektar Therapeutics plans a phase III trial for Alopecia areata in 2026
  • 18 Sep 2025 Efficacy and adverse event data from the phase IIb REZOLVE-AD trial in Atopic dermatitis released by Nektar Therapeutics

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