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Tozorakimab - AstraZeneca

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Drug Profile

Tozorakimab - AstraZeneca

Alternative Names: MEDI-3506

Latest Information Update: 23 Dec 2025

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At a glance

  • Originator MedImmune
  • Developer AstraZeneca
  • Class Anti-inflammatories; Antiasthmatics; Antivirals; Monoclonal antibodies; Skin disorder therapies
  • Mechanism of Action Interleukin-33 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Chronic obstructive pulmonary disease; Respiratory insufficiency
  • Phase II Asthma
  • Discontinued Atopic dermatitis; COVID 2019 infections; Diabetic nephropathies

Most Recent Events

  • 25 Nov 2025 AstraZeneca completes a phase I pharmacokinetics trial (In volunteers) in USA, Germany and UK (SC) (NCT06908577) (CTIS2024-511840-22-00)
  • 12 Apr 2025 AstraZeneca initiates enrolment in the phase-II COMETA trial for Chronic obstructive pulmonary disease (Treatment-experienced) in Russia (SC) (NCT06897748)
  • 07 Apr 2025 AstraZeneca initiates a phase I pharmacokinetics trial (In volunteers) in USA, Germany and UK (SC) (NCT06908577) (CTIS2024-511840-22-00)

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