Either you have JavaScript disabled or your browser does not support Javascript . To work properly, this page requires JavaScript to be enabled.
How to enable JavaScript in your browser?

Sapablursen - Ionis Pharmaceuticals

Next Previous
Drug Profile

Sapablursen - Ionis Pharmaceuticals

Alternative Names: IONIS TMPRSS6-Lrx; IONIS-TMPRSS6-LRx; ISIS-702843; ONO 0530

Latest Information Update: 02 Mar 2026

Price :
$50 *
Note:
  • Adis is an information provider. We do not sell or distribute actual drugs.
  • Final gross price and currency may vary according to local VAT and billing address.
  • Your purchase entitles you to full access to the information contained in our drug profile at the time of purchase.
  • A link to download a PDF version of the drug profile will be included in your email receipt.

At a glance

  • Originator Ionis Pharmaceuticals
  • Class Antineoplastics; Antisense oligonucleotides
  • Mechanism of Action Gene silencing; TMPRSS6 protein expression inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Polycythaemia vera
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Polycythaemia vera
  • Discontinued Beta-thalassaemia; Thalassaemia

Most Recent Events

  • 18 Feb 2026 Ono Pharmaceutical plans a phase III trial for Polycythemia Vera (SC) in June 2026 (NCT07429266)
  • 08 Dec 2025 Adverse events and efficacy data from a phase IIa IMPRSSION trial in Polycythemia vera released by Ono Pharmaceutical
  • 06 Dec 2025 Pharmacodynamics, efficacy and adverse events data from phase II IMPRSSION clinical trials in Polycythaemia vera presented at the 67th American Society of Hematology Annual Meeting and Exposition (ASH-2025)

You need to be a logged in or subscribed to view this content

Request demo (opens in a new window)
If your organization or you do not have a subscription, try one of the following: If your organization has a subscription, there are several access options, even while working remotely:
  • Working within your organization’s network
  • with username/password or try to via your institution
  • Persisted access using your organization’s identifier stored in your user browser for 90 days
Back to top