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RG 7827

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Drug Profile

RG 7827

Alternative Names: FAP-4-1BBL; FAP-4-1BBL FP; RG-7827; RO-7122290

Latest Information Update: 26 Feb 2025

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At a glance

  • Originator Roche Innovation Center Zurich
  • Class Antineoplastics; Immunoglobulin fragments; Immunotherapies; Recombinant fusion proteins
  • Mechanism of Action CD137 antigen agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Colorectal cancer; Solid tumours; Urogenital cancer

Most Recent Events

  • 26 Feb 2025 Discontinued - Phase-I for Solid tumours (Combination therapy, Late-stage disease) in Spain (Parenteral) (Roche pipeline, February 2025)
  • 26 Feb 2025 Discontinued - Phase-I for Solid tumours (Late-stage disease, Monotherapy) in Spain (Parenteral) (Roche pipeline, February 2025)
  • 26 Feb 2025 Discontinued - Phase-I/II for Colorectal cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in United Kingdom, Spain, Netherlands, South Korea, Denmark, Canada (Parenteral) (Roche pipeline, February 2025)

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