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Clemizole - Epygenix Therapeutics/University of California at San Fransisco

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Drug Profile

Clemizole - Epygenix Therapeutics/University of California at San Fransisco

Alternative Names: EPX 100

Latest Information Update: 28 Oct 2025

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At a glance

  • Originator University of California at San Francisco
  • Developer Epygenix Therapeutics
  • Class Antiallergics; Antiepileptic drugs; Antihistamines; Benzimidazoles; Pyrrolidines; Small molecules
  • Mechanism of Action Hepatitis C virus NS4 protein inhibitors; Histamine H1 receptor antagonists; Serotonin 5-HT2 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Epilepsy; Dravet syndrome; Lennox-Gastaut syndrome
  • New Molecular Entity No

Highest Development Phases

  • Phase III Dravet syndrome; Lennox-Gastaut syndrome
  • No development reported Epilepsy

Most Recent Events

  • 28 Oct 2025 No recent reports of development identified for phase-I development in Epilepsy in USA (PO)
  • 15 Jan 2025 Phase-III clinical trials in Lennox-Gastaut syndrome (PO)
  • 31 Dec 2024 Phase-III clinical trials in Lennox-Gastaut syndrome (In children, In adolescents, In adults) in USA (PO), before December 2025 (NCT05066217)

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