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Ifinatamab deruxtecan - Daiichi Sankyo Company

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Drug Profile

Ifinatamab deruxtecan - Daiichi Sankyo Company

Alternative Names: DS-7300; DS-7300a; I-DXd; MK-2400

Latest Information Update: 19 Feb 2026

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At a glance

  • Originator Daiichi Sankyo Company
  • Developer Daiichi Sankyo Company; Merck & Co
  • Class Alkaloids; Antineoplastics; Camptothecins; Drug conjugates; Immunoconjugates; Monoclonal antibodies
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Oesophageal cancer; Prostate cancer; Small cell lung cancer; Squamous cell cancer
  • Phase II Biliary cancer; Bladder cancer; Breast cancer; Cervical cancer; Colorectal cancer; Endometrial cancer; Head and neck cancer; Liver cancer; Malignant melanoma; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer
  • Phase I/II Solid tumours

Most Recent Events

  • 12 Feb 2026 Merck Sharp & Dohme LLC plans a phase I/II trial for Squamous cell cancer (Metastatic disease, Late-stage disease, Inoperable/Unresectable, Second-line therapy or greater) (IV) in March 2026 (NCT07405151)
  • 29 Jan 2026 Phase-I/II clinical trials in Small cell lung cancer (Combination therapy, Late-stage disease) in Israel (IV) (NCT07227597)
  • 17 Oct 2025 Updated efficacy and adverse events data from the phase II IDeate-Lung01 trial in Small cell lung cancer presented at the 50th European Society for Medical Oncology Congress (ESMO-2025)

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