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Ifinatamab deruxtecan - Daiichi Sankyo Company

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Drug Profile

Ifinatamab deruxtecan - Daiichi Sankyo Company

Alternative Names: DS-7300; DS-7300a; I-DXd; MK-2400

Latest Information Update: 08 Jul 2025

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At a glance

  • Originator Daiichi Sankyo Company
  • Developer Daiichi Sankyo Company; Merck & Co
  • Class Alkaloids; Antineoplastics; Camptothecins; Drug conjugates; Immunoconjugates; Monoclonal antibodies
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Prostate cancer; Small cell lung cancer; Squamous cell cancer
  • Phase II Biliary cancer; Bladder cancer; Breast cancer; Cervical cancer; Colorectal cancer; Endometrial cancer; Head and neck cancer; Liver cancer; Malignant melanoma; Non-small cell lung cancer; Oesophageal cancer; Ovarian cancer; Pancreatic cancer
  • Phase I/II Solid tumours

Most Recent Events

  • 25 Jun 2025 Merck Sharp & Dohme initiates a phase I/II IDeate-Prostate02 trial for Prostate cancer (Hormone refractory, Metastatic disease, Second line therapy or greater) (IV, Infusion) (NCT06863272) (EudraCT2024-516036-94)
  • 19 May 2025 Ifinatamab deruxtecan - Daiichi Sankyo Company receives Orphan Drug status for Small cell lung cancer in Japan
  • 19 May 2025 Ifinatamab deruxtecan - Daiichi Sankyo Company receives Orphan Drug status for Small cell lung cancer in Taiwan

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