BPI 002
Alternative Names: BPI-002Latest Information Update: 28 Apr 2021
At a glance
- Originator BeyondSpring Pharmaceuticals
- Class Antineoplastics; Antivirals; Immunotherapies; Small molecules
- Mechanism of Action Cytotoxic T-lymphocyte antigen 4 inhibitors; T lymphocyte stimulants
-
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
- New Molecular Entity Yes
Highest Development Phases
- Preclinical COVID 2019 infections
- No development reported Colorectal cancer
Most Recent Events
- 28 Apr 2021 No recent reports of development identified for preclinical development in Colorectal-cancer in USA (PO)
- 13 Mar 2020 BeyondSpring submits provisional U.S. patent application for BPI 002, for methods of treating viral infections, including COVID-2019 infections
- 13 Mar 2020 Preclinical trials in COVID-2019 infections in USA (PO)
Development Overview
Introduction
BPI 002 is an oral, small-molecule, cytotoxic T-lymphocyte antigen 4 inhibitor (CTLA4 inhibitor), being developed by BeyondSpring as an immuno-oncology agent for the treatment of colon cancer and COVID-2019 infections. Preclinical development is underway in the US.
As at April 2021, no recent reports of development had been identified for preclinical development in Colorectal-cancer in USA (PO).
Key Development Milestones
In March 2020, BeyondSpring reported that BPI 002 can activate the adaptive immune system, including CD4+ helper T cells and CD8+ cytotoxic T cells, to directly attack and kill virally infected cells, including RNA virus, such as those causing COVID-2019. BPI 002 can also potentially function as an adjuvant to provide improved long-term humoral (B-cell dependent) protection against future viral infection, when combined with a vaccine.The company also mentioned that the drug has the potential to directly attack and kill RNA virus without precipitating thereby limiting toxicities [1] .
In preclinical studies in immune competent colon cancer animal model, BPI 002 was synergistic to checkpoint inhibitors [2] .
Patent Information
In March 2020, BeyondSpring reported that the company has submitted provisional U.S. patent application for its pipeline asset BPI-002, for methods of treating viral infections, including COVID-2019 inections, when administered alone or in combination with a vaccine [1] .
As at March 2017, BeyondSpring Pharma owned four pending international patent applications filed under the PCT, which the company planned to file nationally in the US and in other jurisdictions directed to compositions containing BPI 002 and methods of using BPI 002 [2] .
Drug Properties & Chemical Synopsis
- Route of administration PO
- Formulation unspecified
- Class Antineoplastics, Antivirals, Immunotherapies, Small molecules
- Target Cytotoxic T-lymphocyte antigen 4; T lymphocyte
- Mechanism of Action Cytotoxic T-lymphocyte antigen 4 inhibitors; T lymphocyte stimulants
-
WHO ATC code
J05 (Antivirals for Systemic Use)
L01 (Antineoplastic Agents)
-
EPhMRA code
J5 (Antivirals for Systemic Use)
L1 (Antineoplastics)
Development Status
Summary Table
Indication | Qualifier | Patient Segment | Phase | Countries | Route / Formulation | Developers | Event Date |
---|---|---|---|---|---|---|---|
COVID 2019 infections | - | - | Preclinical | USA | PO / unspecified | BeyondSpring Pharmaceuticals | 13 Mar 2020 |
Colorectal cancer | - | - | No development reported (Preclinical) | USA | PO / unspecified | BeyondSpring Pharmaceuticals | 28 Apr 2021 |
Commercial Information
Involved Organisations
Organisation | Involvement | Countries |
---|---|---|
BeyondSpring Pharmaceuticals | Originator | USA |
BeyondSpring Pharmaceuticals | Owner | USA |
Future Events
Development History
Event Date | Update Type | Comment |
---|---|---|
28 Apr 2021 | Phase Change - No development reported | No recent reports of development identified for preclinical development in Colorectal-cancer in USA (PO) Updated 28 Apr 2021 |
13 Mar 2020 | Patent Information | BeyondSpring submits provisional U.S. patent application for BPI 002, for methods of treating viral infections, including COVID-2019 infections [1] Updated 18 Mar 2020 |
13 Mar 2020 | Phase Change - Preclinical | Preclinical trials in COVID-2019 infections in USA (PO) [1] Updated 18 Mar 2020 |
03 Apr 2018 | Trial Update | BeyondSpring plans a phase I trial for Cancer in 2019 [2] [3] Updated 05 Apr 2018 |
28 Apr 2017 | Regulatory Status | BeyondSpring intends to file an IND application for Cancer [4] Updated 14 Jun 2017 |
08 Mar 2017 | Patent Information | BeyondSpring Pharma has pending patents for BPI 002 in USA and other jurisdictions [2] Updated 14 Jun 2017 |
08 Mar 2017 | Phase Change - Preclinical | Preclinical trials in Colorectal cancer in USA (PO) [2] Updated 29 May 2017 |
References
-
BeyondSpring Files for Patent Protection on BPI-002 for the Treatment of Viral Infections Including COVID-19.
Media Release -
Form F-1/A, BeyondSpring Inc., 28 Feb 2017. Internet-Doc 2017;.
Available from: URL: http://ir.beyondspringpharma.com/phoenix.zhtml?c=254429&p=IROL-secToc&TOC=aHR0cDovL2FwaS50ZW5rd2l6YXJkLmNvbS9vdXRsaW5lLnhtbD9yZXBvPXRlbmsmaXBhZ2U9MTE0NTM5NDMmc3Vic2lkPTU3&ListAll=1 -
BeyondSpring Provides Operational Update and Fourth-Quarter and Full-Year 2017 Financial Results.
Media Release -
BeyondSpring Provides Quarterly Operational Update and Full Year 2016 Results.
Media Release
Adis International Ltd. Part of Springer Science+Business Media
© Springer Nature Switzerland AG