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Afamitresgene autoleucel - Adaptimmune

Drug Profile

Afamitresgene autoleucel - Adaptimmune

Alternative Names: ADP A2M4; ADP‑A2M4CD8; afami-cel - adaptimmune; MAGE-A4 SPEAR T-cell therapy; MAGE-A4 TCR; MAGE-A4-SPEAR-T-cell-therapy-Adaptimmune; MAGE-A4ᶜ¹º³²T; Melanoma-associated antigen A4-specific T-cells - Adaptimmune

Latest Information Update: 25 Nov 2021

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At a glance

  • Originator Adaptimmune
  • Developer Adaptimmune; ICON; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Gene therapies; Immunotherapies; T lymphocyte cell therapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Soft tissue sarcoma
  • New Molecular Entity No

Highest Development Phases

  • Phase II Gastric cancer; Head and neck cancer; Myxoid liposarcoma; Oesophageal cancer; Synovial sarcoma
  • Phase I Solid tumours
  • Clinical Phase Unknown Haematological malignancies

Most Recent Events

  • 16 Nov 2021 Adaptimmune withdraws a SPEARHEAD 2 trial in Head and Neck Cancer (Combination therapy, Recurrent, Metastatic disease, Inoperable/Unresectable) in USA (IV) (NCT04408898)
  • 12 Nov 2021 Efficacy data from a phase I trial in various Cancers released by Adaptimmune
  • 12 Nov 2021 Updated efficacy data from the phase I SURPASS trial in Solid tumours released by Adaptimmune
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