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CTL 119

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Drug Profile

CTL 119

Alternative Names: Anti-CD19 CAR-T cell therapy - Novartis/University of Pennsylvania; CTL-119; huCART19; huCTL019

Latest Information Update: 14 Feb 2025

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At a glance

  • Originator University of Pennsylvania
  • Developer Novartis; University of Pennsylvania
  • Class CAR-T cell therapies; Gene therapies; Immunotherapies
  • Mechanism of Action Immunologic cytotoxicity; T lymphocyte replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Precursor cell lymphoblastic leukaemia-lymphoma
  • No development reported B-cell prolymphocytic leukaemia; Chronic lymphocytic leukaemia; Multiple myeloma; Non-Hodgkin's lymphoma

Most Recent Events

  • 07 Dec 2024 Efficacy and adverse events data from a phase I/II trial of Precursor cell lymphoblastic leukaemia-lymphoma presented at the 66th American Society of Hematology Annual Meeting and Exposition (ASH-2024)
  • 28 Sep 2024 No recent reports of development identified for phase-I development in Chronic-lymphocytic-leukaemia(Second-line therapy or greater) in USA (IV, Infusion)
  • 28 Sep 2024 No recent reports of development identified for phase-I development in Multiple-myeloma(Combination therapy) in USA (IV)

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