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BIIB 080

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Drug Profile

BIIB 080

Alternative Names: BIIB080; IONIS BIIB4RX; IONIS MAPTRx; IONIS-MAPTRX; ISIS 814907

Latest Information Update: 02 Apr 2026

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At a glance

  • Originator Ionis Pharmaceuticals
  • Developer Biogen; Ionis Pharmaceuticals
  • Class Antidementias; Antisense oligonucleotides; Neuroprotectants
  • Mechanism of Action Gene silencing; Tau protein expression inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Alzheimer's disease
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease

Most Recent Events

  • 05 Mar 2026 Biogen completes phase I trial (In volunteers) (Intrathecal, Injection) in the USA (NCT06454721)
  • 02 Apr 2025 BIIB 080 receives Fast Track designation for Alzheimer's disease [Intrathecal,Injection] in USA
  • 30 Jan 2025 Biogen initiates enrollment in phase I trial (In volunteers) (Intrathecal, Injection) (NCT06454721)

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