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Diranersen - Biogen

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Drug Profile

Diranersen - Biogen

Alternative Names: BIIB 080; IONIS BIIB4RX; IONIS MAPTRx; IONIS-MAPTRX; ISIS 814907

Latest Information Update: 02 Jul 2026

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At a glance

  • Originator Ionis Pharmaceuticals
  • Developer Biogen; Ionis Pharmaceuticals
  • Class Antidementias; Antisense oligonucleotides; Neuroprotectants
  • Mechanism of Action Gene silencing; Tau protein expression inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Alzheimer's disease
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease

Most Recent Events

  • 29 Jun 2026 Biogen Plans to advance phase III Trial of Diranersen for Alzheimer’s Disease
  • 14 May 2026 Efficacy and adverse events data from a phase II trial in Alzheimer's disease released by Biogen
  • 05 Mar 2026 Biogen completes phase I trial (In volunteers) (Intrathecal, Injection) in the USA (NCT06454721)

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