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Neoantigen DNA vaccine - AstraZeneca/Washington University School of Medicine

Drug Profile

Neoantigen DNA vaccine - AstraZeneca/Washington University School of Medicine

Latest Information Update: 29 Dec 2023

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At a glance

  • Originator MedImmune; Washington University School of Medicine
  • Developer AstraZeneca; Bristol-Myers Squibb; Washington University School of Medicine
  • Class Antigens; Antineoplastics; Cancer vaccines; DNA vaccines; Immunotherapies
  • Mechanism of Action Immunostimulants; T lymphocyte stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Phase II Small cell lung cancer
  • No development reported Prostate cancer; Triple negative breast cancer

Most Recent Events

  • 14 Dec 2023 Washington University School of Medicine in collaboration with Medimmune terminates a phase-I trial in Triple-negative-breast-cancer in USA due to insufficient funding and unavailability of drugs and equipment (NCT03199040),
  • 25 Jul 2022 Bristol-Myers Squibb and Washington University School of Medicine completes a phase I trial in Prostate cancer (Late-stage disease, Metastatic disease, Combination therapy, Second-line therapy or greater) in USA (IM) (NCT03532217)
  • 03 Jun 2022 Safety and immunogenicity data from a phase I trial in prostate cancer presented at the 58th Annual Meeting of the American Society of Clinical Oncology (ASCO-2022)

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