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SYNB 1020

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Drug Profile

SYNB 1020

Alternative Names: SYNB-1020

Latest Information Update: 27 Aug 2019

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At a glance

  • Originator Synlogic
  • Class Probiotics
  • Mechanism of Action Ammonia scavengers; Microbiome modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Inborn urea cycle disorders
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Hyperammonaemia; Inborn urea cycle disorders; Liver cirrhosis

Most Recent Events

  • 20 Aug 2019 Discontinued - Phase-I/II for Hyperammonaemia (In the elderly, In adults), Liver cirrhosis (In the elderly, In adults) and Inborn urea cycle disorders in USA as SYNB 1020 did not indicate an activity profile in ammonia-lowering (PO)
  • 20 Aug 2019 Interim adverse events and pharmacodynamic data from a phase Ia/IIb trial in Cirrhosis and Hyperammonaemia released by Synlogic
  • 16 Jan 2019 Efficacy and safety results from the phase I trial were released by Synlogic

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