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OBI 999

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OBI 999

Alternative Names: Globo H ADC; OBI-999

Latest Information Update: 18 Jan 2024

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At a glance

  • Originator OBI Pharma
  • Class Antineoplastics; Auristatins; Drug conjugates; Immunoconjugates; Immunotoxins; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastric cancer; Pancreatic cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Solid tumours

Most Recent Events

  • 05 Jan 2024 OBI Pharma terminates a phase I/II clinical trials in Solid tumours (Late-stage disease) in USA and Taiwan (IV, Infusion) due to failure to achieve therapeutic potential (NCT04084366)
  • 14 Apr 2023 Pharmacodynamics data from preclinical trials in Solid tumours presented at the 114th Annual Meeting of the American Association for Cancer Research (AACR-2023)
  • 03 Jun 2022 Efficacy, safety and pharmacokinetic data from a phase I part of phase I/II trial in Solid tumours presented at the 58th Annual Meeting of the American Society of Clinical Oncology (ASC0-2022)

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